- - this substance may be of importance
- - Discharge perhaps to be of importance
- - issue of race in sorting out mare
- - this stuff does have importance
- - In substance, that's what's wrong
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- - Substance of genetic importance
- - Double-stranded genetic stuff: Abbr.
- - Counterpart of 58-Across
- - Focus of the Human Genome Project
- - Genetic code
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- - “This royal throne of kings, this sceptered__John of Gaunt in Richard II
- - Small piece of land in the ocean
- - This sceptred ....
- - area of london, .. of dogs
- - I fish, nothing less - plenty of water round here!
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- - "this is your brain … this is your brain on drugs," famously
- - TV spot of Sonic telling you not to do drugs e.g.
- - "this is your brain on drugs" ad, e.g.
- - "This Is Your Brain on Drugs" ad, for one: Abbr.
- - spot on advice?
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- - "This game has been a nail-biter but wait... The ball is in the air again! Will this be the shot that seals the ...?"
- - Seal the ... (make an agreement official)
- - trade in lead production
- - Cope with losing a disorder
- - tourist town in kent that houses two 16th-century castles
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- - Banknotes featuring this living king's visage entered circulation earlier this month
- - king ...... (newly-crowned monarch of the u.k.)
- - King of Spain from 1759-88
- - England's next king, maybe
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- - what you hear in this conversation: "what a nice night we're having in this dark forest!" "yes indeed! ooh, look at that full moon!"
- - Night bird in outside hedges gives a loud cry
- - Cries at the way Les gets disheartened
- - Emulates a coyote
- - Emulates a wolf
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- - Straight to the point … or, homophonically, what this answer is relative to this puzzle?
- - Not left out at the start being outspoken
- - Straight-talking banker? Correct
- - Straight to the point
- - Going straight to the point.
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- - All crossword fans love this puzzle; anyone who doesn't love this puzzle can't be a *real* crossword fan!
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