- - Israel's region
- - Lebanon's locale
- - Palestine's locale
- - Syria's area
- - Hot spot that's a hot spot
- - Area in Asia and Africa
- - Setting of Iran, Iraq and Israel
- - Region spanning three continents
- - Region of long-frustrated peace efforts
- - Hot spot, both literally and figuratively
- - Home of many early civilizations
- - Arabian Peninsula locale
- - Perennial hot spot
- - Biblical setting
- - Frequent Security Council topic
- - Where 29 Down is
- - Spot of conflict
- - Region from Libya to Afghanistan
- - Region in the news
- - Perennial trouble spot
- - Year-round hot spot
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